In public Interest Ministry Of Health and Family Welfare Government Of India has banned manufacture, sale or distribution of 328 FDCs Medicines for human use . This move is taken after supreme court order and after proper investigation by the expert committee.
You can view the official communication regarding the matter here . View Ministry Order Banning 328 Fixed dose Combinations. Below we are giving the list of fixed drug combinations banned recently in September 2018.
| BANNED FIXED DOSE COMBINATION 2018 |
| Aceclofenac (SR) + Paracetamol |
| Aceclofenac + Paracetamol + Famotidine |
| Aceclofenac + Paracetamol + Rabeprazole |
| Aceclofenac + Zinc Carnosine |
| Acetaminophen + Guaifenesin + Dextromethorphan + Chlorpheniramine |
| Acetaminophen + Loratadine + Ambroxol + Phenylephrine |
| Acriflavine + Thymol + Cetrimide |
| Acrivastine + Paracetamol + Caffeine + Phenylephrine |
| Albuterol + Bromhexine + Theophylline |
| Albuterol + Etofylline + Bromhexine + Menthol |
| Alginic Acid + Sodium Bicarbonate + Dried Aluminium Hydroxide + Magnesium Hydroxide |
| Allantoin + Dimethieone + Urea + Propylene + Glycerin + Liquid Paraffin |
| Ambroxol + Levocetirizine + Phenylephrine + Guaiphenesin + Menthol |
| Ambroxol + Guaifenesin + Phenylephrine + Chlorpheniramine |
| Ambroxol + Salbutamol + Choline Theophyllinate + Menthol |
| Ambroxol + Salbutamol + Theophylline |
| Ambroxol + Terbutaline + Dextromethorphan |
| Ambroxol+ Guaiphenesin + Ammonium Chloride + Phenylephrine + Chlorpheniramine Maleate + Menthol |
| Ammonium Chloride + Dextromethorphan + Cetirizine + Menthol |
| Ammonium Chloride + Sodium Citrate + Chlorpheniramine Maleate + Menthol |
| Ammonium Citrate + Vitamin B 12 + Folic Acid + Zinc Sulphate |
| Amoxicillin + Cefixime + Potassium Clavulanic Acid |
| Amoxicillin + Dicloxacillin |
| Amoxicillin 250 mg + Potassium Clavulanate Diluted 62.5 |
| Amoxycillin + Dicloxacillin + Serratiopeptidase |
| Amoxycillin + Tinidazole |
| Ascorbic Acid + Manadione Sodium Bisulphate + Rutin + Dibasic Calcium Phosphate + Adrenochrome mono Se |
| Atorvastatin + Vitamin D3 + Folic Acid + Vitamin B12 + Pyridoxine |
| Azithromycin + Acebrophylline |
| Azithromycin + Ambroxol |
| Azithromycin + Cefixime |
| Azithromycin + Cefpodoxime |
| Azithromycin + Levofloxacin |
| Azithromycin + Ofloxacin |
| Becloemthasone + Clotrimazole + Chloramphenicol + Gentamycin + Lignocaine Ear drops |
| Beclomethasone + Clotimazole + Neomycin + lodochlorohydroxyquinone |
| Beclomethasone + Clotrimazole + Gentamicin + lodochlorhydroxyquinoline |
| Beclomethasone Diproprionate + Neomycin + Tolnaftate + lodochlorhydroxyquinoline + Chlorocresol |
| Benfotiamine + Metformin |
| Benzoxonium Chloride + Lidocaine |
| Betahistine + Ginkgo Biloba Extract + Vinpocetine + Piracetam |
| Betamethasone + Fusidic Acid + Gentamycin + Tolnaftate + lodochlorhydroxyquinoline (ICHQ) |
| Betamethasone + Gentamicin + Tolnaftate + lodochlorhydroxyquinoline |
| Betamethasone + Gentamycin + Zinc Sulphate + Clotrimoazole + Chlorocresol |
| Betamethasone + Neomycin + Tolnaftate + lodochlorohydroxyquinoline + Cholorocresol |
| Borax + Boric Acid + Naphazoline + Menthol + Camphor + Methyl Hydroxy Benzoate |
| Bromhenxine + Phenylephrine + Chlorpheniramine + Paracetamol |
| Bromhexine + Cetrizine + Phenylephrine IP+Guaifenesin + Menthol |
| Bromhexine + Dextromethorphan |
| Bromhexine + Dextromethorphan + Phenylephrine + Menthol |
| Bromhexine + Phenylephrine + Chlorepheniramine Maleate |
| Caffeine + Paracetamol + Chlorpheniramine |
| Caffeine + Paracetamol + Phenylephrine + Cetirizine |
| Calcium Gluconate + Chlorpheniramine + Vitamin C |
| Calcium Gluconate + Levocetirizine |
| Cefixime + Levofloxacin |
| Cefixime + Linezolid |
| Cefpodoxime Proxetil + Levofloxacin |
| Cefuroxime + Linezolid |
| Cephalexin + Neomycin + Prednisolone |
| Certirizine + Phenylephrine + Paracetamol + Caffeine + Nimesulide |
| Cetirizine + Acetaminophen + Dextromethorphan + Phenyephrine + Zinc Gluconate |
| Cetirizine + Ambroxol + Guaiphenesin + Ammonium Chloride + Phenylephrine + Menthol |
| Cetirizine + Dextromethorphan + Ambroxol |
| Cetirizine + Dextromethorphan + Bromhexine + Guaifenesin |
| Cetirizine + Dextromethorphan + Phenylephrine + Tulsi |
| Cetirizine + Dextromethorphan + Phenylephrine + Zinc Gluconate + Paracetamol + Menthol |
| Cetirizine + Dextromethorphan + Zinc Gluconate + Menthol |
| Cetirizine + Diethyl Carbamazine |
| Cetirizine + Phenylephrine + Dextromethorphan + Menthol |
| Cetirizine + Phenylephrine + Paracetamol + Ambroxol + Caffeine |
| Cetirizine + Phenylephrine + Paracetamol + Zinc Gluconate |
| Cetririzine + Nimesulide + Phenylephrine |
| Chlopheniramine Maleate + Dextromethorphan + Guaiphensin + Phenylephrine |
| Chloramphenicol + Beclomethasone + Clomitrimazole + Lignocaine |
| Chloramphennicol + Lignocaine + Betamethasone + Clotrimazole + Ofloxacin + Antipyrine |
| Chlorphaniramine + Ammonium Chloride + Sodium Chloride |
| Chlorpheniramine + Ammonium Chloride + Chloroform + Menthol |
| Chlorpheniramine + Ammonium Chloride + Noscapine + Sodium Citrate |
| Chlorpheniramine + Codeine + Sodium Citrate + Menthol Syrup |
| Chlorpheniramine + Dextromethorphan + Phenylephrine + Paracetamol |
| Chlorpheniramine + Paracetamol + Pseudoephedrine + Caffeine |
| Chlorpheniramine + Phenylephrine + Caffeine |
| Chlorpheniramine + Phenylephrine + Dextromethophan + Menthol |
| Chlorpheniramine + Phenylephrine + Paracetamol + Zink Gluconate |
| Chlorpheniramine + Terpin + Antimony Potassium Tartrate + Ammonium Chloride + Sodium Citrate + Menthol |
| Chlorpheniramine + Vasaka + Tolubalsm + Ammonium Chloride + Sodium Citrate + Menthol |
| Chlorpheniramine + Vitamin C |
| Chlorpheniramine Maleate + Ammonium Chloride + Sodium Citrate |
| Chlorpheniramine+Ammonium Chloride + Menthol |
| Chlorpromazine + Trihexyphenidyl |
| Chromium Polynicotinate + Metformin |
| Cilnidipine + Metoprolol Succinate + Metoprolol Tartrate |
| Ciprofloxacin + Fluocinolone + Clotrimazole + Neomycin + Chlorocresol |
| Ciprofloxacin + Fluticasone + Clotrimazole + Neomycin |
| Ciprofloxacin + Phenazopyridine |
| Clidinium + Paracetamol + Dicyclomine + Activated Dimethicone |
| Clindamycin + Clotrimazole + Lactic Acid Bacillus |
| Clindamycin + Telmisartan |
| Clobetasol + Gentamicin + Tolnaftate + lodochlorhydroxyquinone + Ketoconazole |
| Clobetasol + Neomycin + Miconazole + Clotrimazole |
| Clobetasol + Neomycin + Miconazole + Zinc Sulphate |
| Clobetasol + Ofloxacin + Ketoconazol + Zinc Sulphate |
| Clobetasol + Ofloxacin + Miconazole + Zinc Sulphate |
| Clobetasol Propionate + Ofloxacin + Ornidazole + Terbinafine |
| Clobetasole + Gentamicin + Miconazole + Zinc Sulphate |
| Clomifene Citrate + Ubidecarenone + Zinc + Folic Acid + Methylcobalamin + Pyridoxine + Lycopene + Selenium + Levocarnitine Tartrate + L-Arginine |
| Clotrimazole + Beclomethasone + Lignocaine + Ofloxacin + Acetic Aicd + Sodium Methyl Paraben + Propyl Paraben |
| Clotrimazole + Beclomethasone + Ofloxacin + Lignocaine |
| Clotrimazole + Ofloxaxin + Lignocaine + Glycerine and Propylene Glycol |
| Codeine + Chlorpheniramine + Alcohol Syrup |
| Codeine + Levocetirizine + Menthol |
| Combikit of 3 tablets of Serratiopeptidase (enteric coated 20000 units) + Diclofenac Potassium & 2 tablets of D |
| Combikit of Azithromycin, Secnidazole and Fluconazole |
| Combikit of Fluconazole Tablet, Azithromycin Tablet and Ornidazole Tablets |
| Cyproheptadine + Thiamine |
| Dextrometharphan + Chlopheniramine + Ammonium Chloride+ Menthol |
| Dextrometharphan + Chlopheniramine + Ammonium + Sodium Citrate + Menthol |
| Dextrometharphan + Phenylephrine + Guaiphenesin |
| Dextromethophan + Chlopheniramine + Bromhexine |
| Dextromethorphan + Ambroxol + Ammonium Chloride + Chlorpheniramine + Menthol |
| Dextromethorphan + Ambroxol + Guaifenesin + Phenylephrine + Chlorpheniramine |
| Dextromethorphan + Bromhexine + Guaiphenesin |
| Dextromethorphan + Bromhexine + Guaiphenesin + Menthol |
| Dextromethorphan + Cetirizine |
| Dextromethorphan + Cetirizine + Guaifenesin + Ammonium Chloride |
| Dextromethorphan + Chlorpheniramine + Chlorpheniramine Maleate |
| Dextromethorphan + Chlorpheniramine + Guaiphenesin |
| Dextromethorphan + Levocetirizine + Phenylephrine + Zinc |
| Dextromethorphan + Paracetamol + Cetirizine + Phenylephrine |
| Dextromethorphan + Phenylephrine + Ammonium Chloride + Menthol |
| Dextromethorphan + Phenylephrine + Bromhexine + Guaifenesin + Chlorpheniramine |
| Dextromethorphan + Phenylephrine + Cetirizine + Paracetamol + Caffeine |
| Dextromethorphan + Phenylephrine + Cetirizine + Zinc + Menthol |
| Dextromethorphan + Phenylephrine + Guaifenesin + Certirizine + Acetaminophen |
| Dextromethorphan + Phenylephrine + Guaifenesin + Triprolidine |
| Dextromethorphan + Phenylephrine + Tripolidine + Menthol |
| Dextromethorphan + Phenylephrine + Zinc Gluconate + Menthol |
| Dextromethorphan + Tripolidine + Phenylephirine |
| Dextromethorphan + Triprolidine + Phenylephrine |
| Dextromethorphen + Bromhexine + Chlorpheniramine Maleate + Guaiphenesin |
| Dextromethorphen + Promethazine |
| Diclofenac + paracetamol + chlorpheniramine maleate + mgnesium Trisillicate |
| Diclofenac + Paracetamol + Chlorzoxazone + Famotidine |
| Diclofenac + paracetamol + magnesium Trisilicate |
| Diclofenac + Paracetamol injection |
| Diclofenac + Tramadol + Chlorzoxazone |
| Diclofenac + Tramadol + Paracetamol |
| Diclofenac + Zinc Carnosine |
| Dicyclomine + Paracetamol + Domperidone |
| Diethyl Carbamazine + Chlorpheniramine + Guaifenesin |
| Diethylcabamazine Citrate + Cetirizine + Guaiphenesin |
| Diethylcarbamazine + Cetirizine + Ambroxol |
| Diphenhydramine + Guaifenesin + Bromhexine + Ammonium Chloride + Menthol |
| Diphenhydramine + Guaiphenesin + Ammonium Chloride + Bromhexine |
| Diphenhydramine + Terpine + Ammonium Chloride + Sodium Chloride + Menthol |
| Diphenoxylate + Atropine + Furazolidonee |
| Disodium Hydrogen Citrate + Paracetamol |
| Doxycycline + Serratiopeptidase |
| Doxylamine + Pyridoxine + Mefenamic Acid + Paracetamol |
| Dried Alumnium Hydroxie Gel + Prophantheline + Diazepam |
| Drotaverine + Clidinium + Chlordiazepoxide |
| Enrofloxacin + Bromhexin |
| Ergotamine Tartrate + Belladona Dry Extarct+Caffeine + Paracetamol |
| Ethylmorphine + Noscapine + Chlorpheniramine |
| Famotidine + Oxytacaine + Magaldrate |
| Flunarizine + Paracetamole + Domperidone |
| Flupentixol + Escitalopram |
| Furazolidone + Metronidazole + Loperamide |
| Gabapentin + Mecobalamin + Pyridoxine + Thiamine |
| Gentamicin Sulphate + Clotrimazole + Betamethasone + Lignocaine |
| Gentamycin + Dexamethasone + Chloramphenicol + Tobramycin + Ofloxacin |
| Glibenclamide + Metformin (SR)+ Pioglitazone |
| Gliclazide 40mg + Metformin 400mg |
| Gliclazide 80 mg + Metformin 325 mg |
| Glimepiride + Pioglitazone + Metformin |
| Glimepiride 1mg/2mg/3mg + Pioglitazone 15mg/15mg/15mg + Metformin 1000mg/1000mg/1000mg |
| Glimepiride 1mg/2mg+ Pioglitazone 15mg/15mg + Metformin 850mg/850mg |
| Glipizide 2.5mg + Metformin 400 mg |
| Glucosamine + Methyl Sullfonyl Methane + Vitamin D3 + Manganese + Boron + Copper + Zinc |
| Guaifenesin + Bromhexine + Chlorpheniramine + Paracetamol |
| Guaifenesin + Bromhexine + Chlorpheniramine + Phenylephrine + Paracetamol + Serratiopeptidase (as enteric coated granules) 10000 SP Units |
| Guaifenesin + Dextromethorphan |
| Guaifenesin + Diphenhydramine + Bromhexine + Phenylephrine |
| Heparin + Diclofenac |
| Imipramine + Chlordiazepoxide + Trifluoperazine + Trihexyphenidyl |
| Ketoconazole + Tea Tree oil + Allantion + Zinc Oxide + Aloe Vera + Jojoba oil + Lavander oil + Soa noodels |
| Ketotifen + Cetirizine |
| Ketotifen + Levocetrizine |
| Ketotifen + Theophylline |
| L-5-Methyltetrahydrofolate Calcium + Escitalopram |
| L-Arginine + Sildenafil |
| Levocetirizine + Ambroxol + Phenylephrine + Guaiphenesin |
| Levocetirizine + Ambroxol + Phenylephrine + Paracetamol |
| Levocetirizine + Dextromethorphan + Zinc |
| Levocetirizine + Montelukast + Acebrophylline |
| Levocetirizine + Paracetamol + Phenylephirine + Caffeine |
| Levocetirizine + Phenylephrine + Ambroxol + Guaiphenesin + Paracetamol |
| Levocetirizine + Ranitidine |
| Levofloxacin + Bromhexine |
| Levofloxacin + Ornidazole + Alpha Tocopherol Acetate |
| Levothyroxine + Phyridoxine + Nicotinamide |
| Lignocaine + Clotrimazole + Ofloxacin + Beclomethasone |
| Lornoxicam + Paracetamol + serratiopeptidase |
| Lornoxicam + paracetamol + Tramadol |
| Lornoxicam + paracetamol + trypsin |
| Magaldrate + Famotidine + Simethicone |
| Magaldrate + Papain + Fungul Diastase + Simethicone |
| Magaldrate + Ranitidine + Pancreatin + Domperidone |
| Mebeverine & Inner HPMC capsule (Streptococcus Faecalis + Clostridium butyricum + Bacillus mesentricus + Lactic Acid Bacillus) |
| Menthol + Anesthetic Ether |
| Metformin (SR) 500mg + Pioglitazone 5mg |
| Metformin (Sustainded Release) 500mg + Pioglitazone 15 mg + Glimepiride 3mg |
| Metformin + Atorvastatin |
| Metformin + Bromocriptine |
| Metformin + Gliclazide + Chromium Polynicotinate |
| Metformin + Gliclazide + Piogllitazone + Chromium Polynicotinate |
| Metformin + Glimepiride + Methylcobalamin |
| Metformin 1000/1000/500/500mg + Pioglitazone 7.5/7.5/7.5/7.5mg + Glimepiride 1/2/1/2mg |
| Metformin 500mg/500mg+Gliclazide SR 30mg/60mg + Pioglitazone 7.5mg/7.5mg |
| Metformin 850mg + Pioglitazone 7.5 mg + Glimepiride 1mg |
| Metformin 850mg + Pioglitazone 7.5 mg + Glimepiride 2mg |
| Metformin ER + Gliclazide MR + Voglibose |
| Metronidazole + Norfloxacin |
| Metronidazole + Tetracycline |
| N-Acetyl Cysteine + Ambroxol + Phenylephrine + Levocertirizine |
| Naphazoline + Carboxy Methyl Cellulose + Menthol + Camphor + Phenylephrine |
| Naphazoline + Chlorpheniramine + Zinc Sulphate + Boric Acid + Sodium Chloride + Chlorobutol |
| Naproxen + Paracetamol |
| Neomycin + Doxycycline |
| Nimesulide + Certirizine + Phenylephrine |
| Nimesulide + Cetrizine + Caffeine |
| Nimesulide + Diclofenac |
| Nimesulide + Dicyclomine |
| Nimesulide + Loratadine + Phenylephrine + Ambroxol |
| Nimesulide + Paracetamol + Cetirizine + Phenylephrine |
| Nimesulide + Paracetamol + Levocetirizine + Phenylephrine + Caffeine |
| Nimesulide + paracetamol Injection |
| Nimesulide + Paracetamol Suspension |
| Nimesulide + Phenylephrine + Caffeine + Levocetirizine |
| Nimesulide + Pitofenone + Fenpiverinium + Benzyl Alcohol |
| Nimesulide + Serratiopeptidase |
| Nimesulide + Tizanidine |
| Nimorazole + Ofloxacin |
| Norfloxacin+ Metronidazole + Zinc Acetate |
| Oflaxacin + Ornidazole Suspension |
| Ofloxacin + Clotrimazole + Betamethasone + Lignocaine |
| Ofloxacin + Metronidazole + Zinc Acetate |
| Ofloxacin + Nitazoxanide |
| Ofloxacin + Ornidazole + Zinc Bisglycinate |
| Olmesartan + Hydrochlorothiazide + Chlorthalidone |
| Omepraozle + Paracetmaol+ Diclofenac |
| Oxetacaine + Magaldrate + Famotidine |
| Pantoprazole (as Enteric Coated Tablet) + Zinc Carnosine (as Film Coated Tablets |
| Paracetamol + Ambroxol + Phenylephrine + Chlorpheniramine |
| Paracetamol + Caffeine + Codeine |
| Paracetamol + Caffine + Phenylephrine + Chlorpheniramine |
| Paracetamol + Cetrizine + Caffeine |
| Paracetamol + Chlorpheniramine + Ambroxol + Guaifenesin + Phenylephrine |
| Paracetamol + Codeine + Chlorpheniramine |
| Paracetamol + Dextromethorphan + Bromhexine + Phenylephrine + Diphenhydramine |
| Paracetamol + Dextromethorphan + Chlorpheniramine |
| Paracetamol + Diclofenac + famotidine |
| Paracetamol + Disodium Hydrogen Citrate + Caffeine |
| Paracetamol + DL Methionine |
| Paracetamol + domperidone + Caffeine |
| Paracetamol + Levocetirizine + Phenylephirine + Zink Gluconate |
| Paracetamol + Levocetirizine + Pseudoephedrine |
| Paracetamol + Loratadine + Dextromethophan + Pseudoepheridine + Caffeine |
| Paracetamol + Loratadine + Phenylephrine + Dextromethorphan + Caffeine |
| Paracetamol + mefenamic Acid + ranitidine + Dicyclomine |
| Paracetamol + Pheniramine |
| Paracetamol + Phenylephrine + Chlorpheneramine + Dextromethorphan + caffeine |
| Paracetamol + Phenylephrine + Chlorpheniramine + Zinc Gluconate |
| Paracetamol + Phenylephrine + Desloratadine + Zinc Gluconate + Ambroxol |
| Paracetamol + Phenylephrine + Levocetirizine + Caffeine |
| Paracetamol + Phenylephrine + Triprolidine |
| Paracetamol + Phenylephrine + Triprolidine + Caffeine |
| Paracetamol + Prochloperazine |
| Paracetamol + Prochlorperazine Maleate |
| Paracetamol + Promethazine |
| Paracetamol + Propyphenazone + Caffeine |
| Paracetamol + Pseudoephedrine + Cetrizine |
| Paracetamol + Pseudoephedrine + Dextromethorphan + Cetirizine |
| Paracetamol + Tapentadol |
| Paracetamol+Phenylephrine+Levocetirizine+Sodium Citrate |
| Paracetamol+Pseudoephedrine+Certirizine+Caffeine |
| Permethrin + Cetrimide + Menthol |
| phenylbutazone + sodium salicylate |
| Phenylephrine + Chlorpheniramine + Paracetamol + Bromhexine + Caffeine |
| Pholcodine + Phenylephrine + Promethazine |
| Pioglitazone 15mg + Metformin 850 mg |
| Pioglitazone 30 mg + Metformin 500 mg |
| Pioglitazone 7.5/7.5mg + Metformin 500/1000mg |
| Pseudoephedrine + Bromhexine |
| Pseudoephedrine + Cetirizine |
| Pseudoephedrine + Dextromethorphan + Cetirizine |
| Rabeprazole + Diclofenac + Paracetamol |
| Rabeprazole + Zinc + Domperidone |
| Rabeprazole + Zinc Carnosine |
| Ranitidine + Domperidone + Simethicone |
| Ranitidine + Magaldrate |
| Ranitidine + Magaldrate + Simethicone |
| Roxithromycin + Serratiopeptidase |
| Salbutamol + Aminophylline + Guaiphensin |
| Salbutamol + Bromhexine + Guaiphenesin + Menthol |
| Salbutamol + Certirizine + Ambroxol |
| Salbutamol + Choline Theophylinate + Ambroxol |
| Salbutamol + Choline Theophylinate + Carbocisteine |
| Salbutamol + Theophylline + Bromhexine |
| Salbutamol+Hydroxyethyltheophylline (Etofylline) + Bromhexine |
| Sildenafil + Estradiol Valerate |
| Tamsulosin + Diclofenac |
| Telmisartan + Metformin |
| Terbutaline + Ambroxol + Guaiphenesin + Zinc + Menthol |
| Terbutaline + Bromhexine + Etofylline |
| Terbutaline + Bromhexine + Guaiphenesin + Dextromethorphan |
| Terbutaline + Etofylline + Ambroxol |
| Terbutaline + N-Acetyl L-Cysteine + Guaifenesin |
| Terpinhydrate + Dextromethorphan + Menthol |
| Thyroid + Thiamine + Riboflavin + Phyridoxine + Calcium Pantothenate + Tocopheryl Acetate + Nicotinamide |
| Thyroxine + Pyridoxine + Folic Acid |
| Tranexamic Acid + Proanthocyanidin |
| Ursodeoxycholic Acid + Silymarin |
| Voglibose + Pioglitazone + Metformin |
| Voglibose+ Metformin + Chromium Picolinate |
| Zinc Carnosine + Magnesium Hydroxide + Dried Aluminium Hydroxide + Simethicone |
| Zinc Carnosine + Oxetacaine |
| Zinc Carnosine + Sucralfate |
So if you are a pharmacist, doctor or a concerned citizen. Kindly do take notice and modify the practice of medication towards rational drug use. After a prescription is written pharmacist as being a direct point of contact has responsibility to apply knowledge for rational drug use. Pharmacy practice act made it clear that prescription assessment by pharmacist is effective way for ensuring better public health, minimising the effects and increasing effectiveness of therapy. Doctors and Pharmacists should ensure that they collaborate with spirit of helping the patients; ensuring proper medication and personalised dose to the patients.